Comparative studies on some local anesthetics
نویسندگان
چکیده
منابع مشابه
Local Anesthetics Properties of Local Anesthetics
The first clinical uses of a local anesthetic agent occurred in 1884, when cocaine was employed as a topical agent for eye surgery and to produce a nerve block. These events inaugurated a new era, that of regional anesthesia. New applications were developed, including spinal, epidural, and caudal anesthesia. The search for a better local anesthetic led to chemical synthesis of a number of other...
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A review of the results obtained by our group in the last decade regarding the interactions of procaine, lidocaine, dibucaine and tetracaine with membranes is presented in the context of the literature data. The action upon membranes, in first approximation monomolecular film of stearic acid spread at the air/water interface used as a membrane model, the modification of biomembrane structure an...
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In recent years levobupivacaine, the pure S (-)-enantiomer of bupivacaine, emerged as a safer alternative for regional anesthesia than its racemic parent. It demonstrated less affinity and strength of depressant effects onto myocardial and central nervous vital centers in pharmacodynamic studies, and a superior pharmacokinetic profile. Clinically, levobupivacaine is well tolerated in a variety ...
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a Istanbul Aydın University, Vocational School of Health Services, Department of Anesthesiology, Istanbul, Turkey b University of Beykent, School of Medicine, Department of General Surgery, Istanbul, Turkey c Karadeniz Technical University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Trabzon, Turkey d Istanbul University, Cerrahpasa Medical Faculty, Department of Histolog...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 1957
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.53.861